The difference between people who get the influenza virus (coronavirus) and people who don’t(English)

Elucidation of the function of the glycan molecule that binds influenza virus

The mechanism by which the influenza A virus multiplies in the human body is as follows. (Figure 1.)
N-acetylneuraminic acid (Neu5Ac), one of the sialic acid molecular species, is the best known glycan molecule to which influenza type A virus binds.

While Neu5Ac at the end of the sugar chain on the cell surface acts as a receptor to initiate infection of influenza A virus, some influenza A viruses bind not only Neu5Ac but also N- glyceryl neuraminate (Neu5Gc), one of the main molecular species of sialic acid.

According to the Ministry of Health, Labour and Welfare, the domestic influenza virus for 2019-2020 is 73% AH1pdm09 for human type A, 17% AH3 subtype and 10% human type B.

AH1pdm09 is the virus that caused the global pandemic in 2009.

This influenza A virus binds to the human cell surface via the sugar chain N-acetylneuraminic acid (Neu5Ac) on the cell surface and infiltrates the cell by endocytosis and infects it.

However, the cell surface sugar chain N-glyceryl neulaminate (Neu5Gc) has been shown to inhibit infection. (Figure 1.)

Translated with (free version)

However, people cannot produce N-Glyceryl Neuraminate (Neu5Ac) in their bodies, so they have to take it from food.

Shoki T-1 contains 8 types of monosaccharides and the amino acids necessary for N-type carbohydrate binding.

The combination ratio of these eight types of monosaccharides and amino acids allows Shoki T-1 to increase the N-type sugar chain of N-glyceryl neuraminic acid (Neu5Gc) on the cell surface.

Reference Paper: 2015 Sugiura Award for Best Paper [Viruses, Vol. 66, No. 1, pp. 101-116, 2016].

Taking Shoki T-1 leads to the prevention of influenza by increasing the sugar chain N-glyceryl neuraminic acid (Neu5Gc) on the cell surface.

A new type of coronavirus, which could cause a global pandemic, is also now a single-stranded RNA virus like the influenza virus.

The proliferation pathway of the single-stranded RNA virus adheres to the cell with the N-type sugar chain of the human cell epidermis as a mark and infiltrates into the cell, but the sugar chain that promotes antibody production and inhibits the infiltration of the virus also exists in the N-type sugar chain of the human cell epidermis.

Shoki T-1 contains 8 types of monosaccharides and N-type glycans that promote the production of antibodies on the cell surface by combining amino acids necessary for N-type glycan binding.

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