Elucidation of the function of the glycan molecule that binds influenza virus
The mechanism by which the influenza A virus multiplies in the human body is as follows. (Figure 1.)
N-acetylneuraminic acid (Neu5Ac), one of the sialic acid molecular species, is the best known glycan molecule to which influenza type A virus binds.
While Neu5Ac at the end of the sugar chain on the cell surface acts as a receptor to initiate infection of influenza A virus, some influenza A viruses bind not only Neu5Ac but also N- glyceryl neuraminate (Neu5Gc), one of the main molecular species of sialic acid.
According to the Ministry of Health, Labour and Welfare, the domestic influenza virus for 2019-2020 is 73% AH1pdm09 for human type A, 17% AH3 subtype and 10% human type B.
AH1pdm09 is the virus that caused the global pandemic in 2009.
This influenza A virus binds to the human cell surface via the sugar chain N-acetylneuraminic acid (Neu5Ac) on the cell surface and infiltrates the cell by endocytosis and infects it.
However, the cell surface sugar chain N-glyceryl neulaminate (Neu5Gc) has been shown to inhibit infection. (Figure 1.)
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However, people cannot produce N-Glyceryl Neuraminate (Neu5Ac) in their bodies, so they have to take it from food.
Shoki T-1 contains 8 types of monosaccharides and the amino acids necessary for N-type carbohydrate binding.
The combination ratio of these eight types of monosaccharides and amino acids allows Shoki T-1 to increase the N-type sugar chain of N-glyceryl neuraminic acid (Neu5Gc) on the cell surface.
Taking Shoki T-1 leads to the prevention of influenza by increasing the sugar chain N-glyceryl neuraminic acid (Neu5Gc) on the cell surface.
A new type of coronavirus, which could cause a global pandemic, is also now a single-stranded RNA virus like the influenza virus.
The proliferation pathway of the single-stranded RNA virus adheres to the cell with the N-type sugar chain of the human cell epidermis as a mark and infiltrates into the cell, but the sugar chain that promotes antibody production and inhibits the infiltration of the virus also exists in the N-type sugar chain of the human cell epidermis.
Shoki T-1 contains 8 types of monosaccharides and N-type glycans that promote the production of antibodies on the cell surface by combining amino acids necessary for N-type glycan binding.